How Long Do Semaglutide Side Effects Last?
Most semaglutide side effects are temporary and improve within weeks. Learn what symptoms are common, how long they last, and when to seek medical care.
Semaglutide, like all medications, can cause side effects — but most are temporary.
The most common side effects are gastrointestinal issues like nausea, vomiting, diarrhea, constipation, or abdominal discomfort. These often occur when starting the drug or increasing your dose and usually improve within the first few weeks as your body gets used to the medication.
Other common issues like slight headaches or fatigue can appear initially but typically resolve within days to a few weeks. Injection‑site reactions (redness, swelling) are usually very short‑lived (a few days).
Serious side effects — e.g., gallbladder pain, pancreatitis symptoms — are rare but require immediate medical attention. These do not resolve on their own and usually mean stopping the medication.
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